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عمومی::
بیماری پرولیفراتیو
Theoretically, oxygen in phase 2 of retinopathy of prematurity could suppress high concentrations of oxygen-regulated growth factors such as VEGF that cause proliferative disease.
Investigators of the STOP-ROP study59 reported no change in progression of prethreshold retinopathy of prematurity to proliferative disease after increasing oxygen saturation to 96-99% from the conventional 89-94% for at least 2 weeks.
However, with only serial weight measurements (once per week from birth to 32 weeks postmenstrual age), WINROP also identified early all 35 of the 353 infants in a study98 who later developed proliferative retinopathy of prematurity that required treatment and 76% (268/353) of those who did not develop proliferative disease.
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